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A MySebDermTeam Member asked a question 💭
Columbia, MD
April 24
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Is Zoryve (roflumilast) effective for seborrheic dermatitis? The short answer is: yes, the clinical trial results look pretty promising!

Zoryve foam was FDA-approved in December 2023 for people aged 9 and older. It's a once-daily, steroid-free foam that works by reducing inflammation through a mechanism called PDE4 Show Full Answer

Is Zoryve (roflumilast) effective for seborrheic dermatitis? The short answer is: yes, the clinical trial results look pretty promising!

Zoryve foam was FDA-approved in December 2023 for people aged 9 and older. It's a once-daily, steroid-free foam that works by reducing inflammation through a mechanism called PDE4 inhibition — basically, it helps calm the immune response that triggers seborrheic dermatitis symptoms. Here's what the clinical trial (called the Stratum phase 3 study) found after 8 weeks of use:

- 80% of users achieved clear or almost clear skin
- 50% experienced complete clearance of skin symptoms
- 60%+ had a significant reduction in itch severity
- 28% felt improvement within just 2 days
- Some participants saw noticeable improvement as early as week two

The treatment was also reported to be safe and well tolerated.

It's worth having a conversation with your dermatologist to see if Zoryve could be a good fit for your specific situation, as everyone's skin responds differently.

April 24

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